Thionyl Chloride → HCID 68418272, compound

HRID 2387876Notes

Reaction equation

HRID 2387876 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]=1[CH2:19]O)[C:12]([O:14][CH3:15])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:23])=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]=1[CH2:19][Cl:23])[C:12]([O:14][CH3:15])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 68412548HCID 68412548, compound

Product 1

HCID 68418272HCID 68418272, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

The product of step (iii) (9.5 g) was dissolved in DCM (200 ml), cooled to 0° C. and thionyl chloride (3.57 ml) was added and stirred at rt for 2 h. The solvents were evaporated and the residue taken up in DCM and washed with aq. NaHCO3. The combined organics were dried, filtered and evaporated to give the subtitle compound as a brown oil, 9.60 g.

Workup

  1. customThe solvents were evaporated
  2. washwashed with aq. NaHCO3
  3. customThe combined organics were dried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-ef2267681ea7476c97c666aa469d5d28
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

Loading…