HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2387892Generated: October 27, 2026
Hydrochloric Acid → Methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate
https://huagongshe.com/reaction/2387892
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 2-(3-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid | HCID 68952062 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate | HCID 42613821 | — |
Reaction Steps
4M HCl in dioxane (1 mL) was added to a stirred suspension of the product from step (iv) (650 mg) in MeOH (2 mL). The suspension was heated at 60° C. for 2 h. The solvent was evaporated under reduced pressure to give the subtitle compound as a brown solid, 630 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08268990B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-286c62b6173a424b83f8686c3ebea2fd |
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| Source note | uspto-grants-2012_09 |
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