Hydrochloric Acid → Methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate

HRID 2387892Notes

Reaction equation

Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:6]([CH2:14][C:15]2[CH:16]=[C:17]([CH2:23][C:24]([OH:26])=[O:25])[CH:18]=[CH:19][C:20]=2[O:21][CH3:22])=[C:5]([CH3:27])[N:4]=1.O1CCOC[CH2:29]1>CO>[NH2:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:6]([CH2:14][C:15]2[CH:16]=[C:17]([CH2:23][C:24]([O:26][CH3:29])=[O:25])[CH:18]=[CH:19][C:20]=2[O:21][CH3:22])=[C:5]([CH3:27])[N:4]=1

Participants

Conditions

Temperature: 60 °C

Procedure

4M HCl in dioxane (1 mL) was added to a stirred suspension of the product from step (iv) (650 mg) in MeOH (2 mL). The suspension was heated at 60° C. for 2 h. The solvent was evaporated under reduced pressure to give the subtitle compound as a brown solid, 630 mg.

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-286c62b6173a424b83f8686c3ebea2fd
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08268990B2

Reaction notes

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