Pentylamine → HCID 68955280, compound

HRID 2387895Notes

Reaction equation

HRID 2387895 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:16][C:17]#[N:18])[CH:13]=[CH:14][CH:15]=2)=[C:4]([CH3:19])[N:3]=1.[CH2:20]([NH2:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(O)CCC>[NH2:1][C:2]1[N:3]=[C:4]([CH3:19])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:16][C:17]#[N:18])[CH:13]=[CH:14][CH:15]=2)=[C:6]([NH:25][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[N:7]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 86633416HCID 86633416, compound

Product 1

HCID 68955280HCID 68955280, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
110 °C

Procedure

The product from step (iii) (Ig) was combined with butan-1-ol (25 mL) and pentan-1-amine (4 mL) was added. The reaction mixture was heated to 110° C. for 18 h. The solvents were evaporated and the product purified using chromatography to give the subtitle compound as an orange oil, 600 mg.

Workup

  1. additionwas added
  2. customThe solvents were evaporated
  3. customthe product purified

Sources & evidence

ORD record
ord-6a9f034aa561408bae7b427948650613
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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