HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 68413953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)methanol | HCID 68415232 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68413953 | HCID 68413953 | — |
Reaction Steps
The product from step (iii) (2.2 g) in DCM (100 mL) was cooled to 0° C. and SOCl2 (0.486 ml) was added dropwise. The reaction was allowed to warm up to rt over 1 hr, and poured cautiously into sat. NaHCO3 and the aqueous phase was separated. The organic phase was dried, filtered and the solvent evaporated under reduced pressure to give the subtitle compound as a yellow solid, 2.260 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-d5156d87a0804510a34c24f2c3b9c9a0 |
| Source note | uspto-grants-2012_09 |