Thionyl Chloride → HCID 178433377, compound

HRID 2387906Notes

Reaction equation

HRID 2387906 reaction equation
O=S(Cl)[Cl:3].[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]O)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>C(Cl)Cl>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][Cl:3])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178433379HCID 178433379, compound

Product 1

HCID 178433377HCID 178433377, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

SOCl2 (20 ml) was added slowly to a stirred mixture of the product from step (i) (6.7 g) in DCM (50 ml) and stirred at rt for 24 h. The solvent was evaporated under reduced pressure to give the title compound, 8.7 g.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-375d893d8c2847f3b479921493a68464
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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