p-(Trifluoromethoxy)benzenesulphonyl chloride → N-(5-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethoxy)benzenesulfonamide

HRID 2388059Notes

Reaction equation

HRID 2388059 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[F:20][C:21]([F:34])([F:33])[O:22][C:23]1[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][S:29]([C:26]2[CH:25]=[CH:24][C:23]([O:22][C:21]([F:20])([F:33])[F:34])=[CH:28][CH:27]=2)(=[O:31])=[O:30])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

3

Reactant 2

HCID 523102p-(Trifluoromethoxy)benzenesulphonyl chlorideHCID 687937575-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852474N-(5-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethoxy)benzenesulfonamide

Procedure

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 2) and 4-(trifluoromethoxy)benzene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-d21ccdaeeeac41049af1843ac80c0a77
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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