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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2388059Generated: October 26, 2026

p-(Trifluoromethoxy)benzenesulphonyl chloride → N-(5-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethoxy)benzenesulfonamide

https://huagongshe.com/reaction/2388059

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-(Trifluoromethoxy)benzenesulphonyl chlorideHCID 523102—
Reactant5-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amineHCID 68793757—
ProductN-(5-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethoxy)benzenesulfonamideHCID 24852474—

Reaction Steps

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 2) and 4-(trifluoromethoxy)benzene-1-sulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08269010B2
Source datasetuspto-grants-2012_09
ORD IDord-d21ccdaeeeac41049af1843ac80c0a77
Source noteuspto-grants-2012_09