2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride → HCID 24852701, compound

HRID 2388074Notes

Reaction equation

HRID 2388074 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[Cl:20][C:21]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=1[S:31](Cl)(=[O:33])=[O:32]>>[Cl:20][C:21]1[CH:26]=[C:25]([C:27]([F:29])([F:28])[F:30])[CH:24]=[CH:23][C:22]=1[S:31]([NH:19][C:4]1[CH:5]=[N:6][C:7]([O:8][C:9]2[CH:10]=[N:11][C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:2]([Cl:1])[CH:3]=1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 27366752-Chloro-4-(trifluoromethyl)benzenesulfonyl chlorideHCID 687907985-Chloro-6-(quinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852701HCID 24852701, compound

Procedure

The title compound was prepared by reacting 5-chloro-6-(quinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 1) and 2-chloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride. 1H NMR (DMSO-d6) δ: 7.60 (s, 1H), 7.72-7.77 (m, 3H), 7.90 (s, 2H), 8.00 (s, 1H), 8.13-8.20 (m, 3H), 8.75 (s, 1H), 11.21 (s, 1H); MS (ES): 513.99 (M+1).

Sources & evidence

ORD record
ord-1f3d57e264754b6f9db350c26d4c7886
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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