Succinic anhydride → 4-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-ylamino)-4-oxobutanoic acid

HRID 2388090Notes

Reaction equation

HRID 2388090 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[C:20]1(=[O:26])[O:25][C:23](=[O:24])[CH2:22][CH2:21]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][C:20](=[O:26])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 687907985-Chloro-6-(quinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 248530294-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-ylamino)-4-oxobutanoic acid

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

5-Chloro-6-(quinolin-3-yloxy)-pyridin-3-yl amine (1 mmol) (obtained as per procedure described in preparation 1) was dissolved in toluene under heating. To the clear solution was added succinic anhydride (1 mmol) and refluxed at 120° C. for 6 hours. The solvent the evaporated and the crude obtained was purified by column chromatography to provide the title compound.

Workup

  1. temperatureunder heating
  2. customThe solvent the evaporated
  3. customthe crude obtained
  4. customwas purified by column chromatography

Sources & evidence

ORD record
ord-d8d5e90c7d7b4212a05a7bed708911c7
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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