関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | 5-Chloro-6-(quinolin-3-yloxy)pyridin-3-amine | HCID 68790798 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-ylamino)-4-oxobutanoic acid | HCID 24853029 | — |
反応手順
5-Chloro-6-(quinolin-3-yloxy)-pyridin-3-yl amine (1 mmol) (obtained as per procedure described in preparation 1) was dissolved in toluene under heating. To the clear solution was added succinic anhydride (1 mmol) and refluxed at 120° C. for 6 hours. The solvent the evaporated and the crude obtained was purified by column chromatography to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08269010B2 |
|---|
| 出典データセット | uspto-grants-2012_09 |
|---|
| ORD ID | ord-d8d5e90c7d7b4212a05a7bed708911c7 |
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| 出典メモ | uspto-grants-2012_09 |
|---|
