反应详情

Hydroxylamine hydrochloride (3.2 g, 46.3 mmol) and sodium acetate (3.8 g, 46.3 mmol) were added to 20 mL of methanol and the resulting white slurry was stirred at room temperature for 30 min. 1-(Thiophen-2-yl)propan-1-one (5.9 g, 42.1 mmol) was added and the mixture was stirred at room temperature for 20 hours. Water (20 mL) was added and the product was extracted with EtOAc and the organic layer was washed with saturated NaHCO3 solution and dried over MgSO4. The solvent was evaporated in vacuo to give 6.3 g of the title compound. MS: (+) m/z 156.32 (M+1).

1. stirringthe mixture was stirred at room temperature for 20 hours
2. extractionthe product was extracted with EtOAc
3. washthe organic layer was washed with saturated NaHCO3 solution
4. dry with materialdried over MgSO4
5. customThe solvent was evaporated in vacuo