Trifluoroacetic acid → Trifluoroacetic acid

HRID 2388356Notes

Reaction equation

HRID 2388356 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:11][N:10]([CH:12]2[CH2:17][CH2:16][CH:15]([C:18]3[N:22]=[C:21]([C:23]([Cl:26])([Cl:25])[Cl:24])[O:20][N:19]=3)[CH2:14][CH2:13]2)[CH2:9]1)(C)(C)C.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[Cl:25][C:23]([Cl:24])([Cl:26])[C:21]1[O:20][N:19]=[C:18]([CH:15]2[CH2:16][CH2:17][CH:12]([N:10]3[CH2:11][CH:8]([NH2:7])[CH2:9]3)[CH2:13][CH2:14]2)[N:22]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59541793{1-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-yl}-carbamic acid tert-butyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 595418221-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-ylamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

{1-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-yl}-carbamic acid tert-butyl ester (as prepared in the previous step) was treated with 1:1 ratio of DCM and TFA at room temperature. After 2 hours, the solvent was removed in vacuo and the residue was dried overnight to give the title compound as TFA salt (colorless oil).

Workup

  1. customthe solvent was removed in vacuo
  2. customthe residue was dried overnight

Sources & evidence

ORD record
ord-9f44ae578299430c8a4cc7e8e94b6d4b
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

Loading…