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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2388357Generated: November 2, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-({1-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

https://huagongshe.com/reaction/2388357

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
Reactant((3-(Trifluoromethyl)benzoyl)amino)acetic acidHCID 2777432—
Reactant1-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-ylamineHCID 59541822—
ProductN-({1-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamideHCID 46946854—

Reaction Steps

The title compound was prepared by the EDCI coupling of 1-[4-(5-trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-ylamine (as prepared in the previous step) and (3-trifluoromethyl-benzoylamino)-acetic acid (Bionet Building Blocks). Purification by HPLC gave cis and trans isomers.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08269015B2
Source datasetuspto-grants-2012_09
ORD IDord-f72a67e1a8ea42729b24c102ce245a31
Source noteuspto-grants-2012_09