反应详情

tert-Butyl 2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)acetate (124.5 g, 321.3 mmol) was dissolved in THF (1,150 ml) and MeOH (1,900 ml), and an aqueous 6 M NaOH solution (1,300 ml) was added. The reaction mixture was stirred at room temperature for 1 hour and the organic solvents were then distilled off. The residue was taken up in aqueous 6 M HCl (2,000 ml) at 0° C. and the mixture was extracted with methylene chloride (2×1,000 ml). The combined organic phases were dried, filtered and concentrated to dryness in vacuo. The yield was 103.5 g (97%).

1. distillationthe organic solvents were then distilled off
2. customwas taken up in aqueous 6 M HCl (2,000 ml) at 0° C.
3. extractionthe mixture was extracted with methylene chloride (2×1,000 ml)
4. customThe combined organic phases were dried
5. filtrationfiltered
6. concentrationconcentrated to dryness in vacuo