Trifluoroacetic acid → HCID 57916235, compound

HRID 2388662Notes

Reaction equation

HRID 2388662 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[S:9]([N:12]([CH2:16][CH2:17][O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:13]1[CH2:15][CH2:14]1)(=[O:11])=[O:10].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[S:9]([N:12]([CH2:16][CH2:17][O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:13]1[CH2:14][CH2:15]1)(=[O:10])=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57916276tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetate

Product 1

HCID 57916235HCID 57916235, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a dichloromethane (10 ml/mmol) solution of tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetate (1 eq.) was added trifluoroacetic acid (13 eq.) at 0° C. and the resulting reaction mixture was stirred at ambient temperature for 2 h. The solvent was evaporated off and the residue dried under vacuum to remove traces of trifluoroacetic acid. The crude product was used in the next step without further purification. Yield: quantitative

Workup

  1. customthe resulting reaction mixture
  2. customThe solvent was evaporated off
  3. customthe residue dried under vacuum
  4. customto remove traces of trifluoroacetic acid
  5. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-b0de5525e311437eb2cd016bd7b2640e
Source dataset
uspto-grants-2012_09
Patent number
US08268814B2

Reaction notes

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