反应详情

tert-Butyl 2-(azetidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate (0.28 g, 0.908 mmol) was dissolved in methanol (1 ml) and HCl in methanol (1.25 M, 3.63 ml, 4.54 mmol) was added. The reaction mixture was heated at reflux for 1 h. After cooling to room temperature the solvent was removed in vacuo. The crude product was re-dissolved in ethanol, diethylether was added and the mixture was stirred at 0° C. for 20 min. The solid was collected by filtration, washed with diethylether and dried in vacuo. Yield: 0.2 g (78%).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1 h
3. customwas removed in vacuo
4. dissolutionThe crude product was re-dissolved in ethanol
5. additiondiethylether was added
6. filtrationThe solid was collected by filtration
7. washwashed with diethylether
8. customdried in vacuo