Hydrochloric Acid → HCID 68643961, compound

HRID 2388722Notes

Reaction equation

HRID 2388722 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[S:9][C:10]3[CH2:11][N:12](C(OCC)=O)[CH2:13][CH2:14][C:15]=3[N:16]=2)=[CH:3][CH:2]=1.[OH-].[K+].[ClH:24]>>[ClH:24].[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[S:9][C:10]3[CH2:11][NH:12][CH2:13][CH2:14][C:15]=3[N:16]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 68643971HCID 68643971, compound

Product 1

HCID 68643961HCID 68643961, compound

Conditions

Temperature
0 °C

Procedure

A solution of ethyl 2-(pyridin-4-ylmethyl)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (3.7 mmol) in a 3.5 N potassium hydroxide solution (7 ml) was heated under reflux for 3 hours. The course of the reaction was monitored by thin layer chromatography. The reaction mixture was then cooled to 0° C. and acidified with concentrated hydrochloric acid. The solid which precipitated was filtered out and dried. The product was obtained in the form of the HCl salt. The desired product was obtained in a yield of 35%.

Workup

  1. temperatureunder reflux for 3 hours
  2. customThe solid which precipitated
  3. filtrationwas filtered out
  4. customdried

Sources & evidence

ORD record
ord-31a6b9fb97d048f6a8e8b9b269d95a14
Source dataset
uspto-grants-2012_09
Patent number
US08268814B2

Reaction notes

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