Sulfamide → 4-Pyrimidin-2-ylpiperazine-1-sulfonamide

HRID 2388803Notes

Reaction equation

HRID 2388803 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[S:13](N)([NH2:16])(=[O:15])=[O:14]>O1CCOCC1>[N:12]1[CH:11]=[CH:10][CH:9]=[N:8][C:7]=1[N:1]1[CH2:6][CH2:5][N:4]([S:13]([NH2:16])(=[O:15])=[O:14])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 82267SulfamideHCID 887471-(2-Pyrimidinyl)piperazine

Product 1

HCID 115722974-Pyrimidin-2-ylpiperazine-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The subtitle compound was prepared according to the procedure outlined in example 15 step i) using 2-piperazin-1-ylpyrimidine (3.0 g) and sulfamide (1.2 g) in dioxane (30 mL) to give the subtitle compound as a white solid. Yield: 2.06 g.

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-7984eae2c9a34110b069e2f173b51d2b
Source dataset
uspto-grants-2012_09
Patent number
US08269002B2

Reaction notes

Loading…