反应详情

To a solution of ethyl (2R)-2-[(2-[(2,3-difluorobenzyl)thio]-6-{[(9-methyl-3,9-diazabicyclo[4.2.1]non-3-yl)sulfonyl]amino}pyrimidin-4-yl)oxy]propanoate (the product from step i), 0.35 g) in THF (10 ml) was added 2 M LiBH4 in TI-IF (0.6 ml). The reaction was then stirred for 18 h at room temperature. Saturated NH4Cl (150 ml) was then added to the reaction mixture which was extracted with DCM (3×150 ml). Organics were combined, dried (MgSO4) and reduced in vacuo and the resulting residue was purified by prep HPLC to give the title compound as a white solid. Yield 20 mg

1. extractionwas extracted with DCM (3×150 ml)
2. dry with materialdried (MgSO4)
3. customthe resulting residue was purified by prep HPLC