HCID 86619885, compound → 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

HRID 2388841Notes

Reaction equation

HRID 2388841 reaction equation
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

Participants

3

Reactant 1

HCID 86619885HCID 86619885, compound2×

Product 1

HCID 52261,2,3,4-tetrahydroisoquinoline-7-sulfonamide

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

Workup

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

Sources & evidence

ORD record
ord-dad070b6548e4e229595b46ac85a0933
Source dataset
uspto-grants-2012_09
Patent number
US08269002B2

Reaction notes

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