Trifluoroacetic acid → HCID 59558821, compound

HRID 2388875Notes

Reaction equation

HRID 2388875 reaction equation
COC1C=CC(C[N:10]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[N:21]=[C:20]([S:26][CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:19]=2)[S:11]([N:14]2[CH2:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])=CC=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:25][O:24][C:22]1[N:21]=[C:20]([S:26][CH2:27][CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[N:19]=[C:18]([NH:10][S:11]([N:14]2[CH2:17][CH2:16][CH2:15]2)(=[O:12])=[O:13])[CH:23]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67051248HCID 67051248, compound

Product 1

HCID 59558821HCID 59558821, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of N-[(4-methoxyphenyl)methyl]-N-[6-methoxy-2-[(2-phenylethyl)thio]pyrimidin-4-yl]azetidine-1-sulfonamide (the product of step iii, 0.17 g) in DCM (1 ml) and TFA (2 ml) was stirred at room temperature for 18 h. The solvent was evaporated under reduced pressure. The residue was recrystallised from EtOAc and iso-hexane to give the title product as a white solid. Yield: 50 mg.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallised from EtOAc and iso-hexane

Sources & evidence

ORD record
ord-c12ca7409bd64e8783cdb42c8bf2a863
Source dataset
uspto-grants-2012_09
Patent number
US08269002B2

Reaction notes

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