1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 25027637, compound

HRID 238888Notes

Reaction equation

HRID 238888 reaction equation
C[O:2][C:3](=[O:21])[C:4]([NH:7][C:8]([C:10]1[C:11]([OH:20])=[C:12]2[C:16](=[C:17]([CH3:19])[CH:18]=1)[CH2:15][CH2:14][CH2:13]2)=[O:9])([CH3:6])[CH3:5].Br[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=1>>[CH3:6][C:4]([NH:7][C:8]([C:10]1[C:11]([O:20][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:28][CH:29]=2)=[C:12]2[C:16](=[C:17]([CH3:19])[CH:18]=1)[CH2:15][CH2:14][CH2:13]2)=[O:9])([CH3:5])[C:3]([OH:2])=[O:21]

Participants

3

Reactant 2

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 57912189HCID 57912189, compound

Product 1

HCID 25027637HCID 25027637, compound

Procedure

2-Methyl-2-{[7-methyl-4-(4-trifluoromethyl-benzyloxy)-indane-5-carbonyl]-amino}-propionic acid was prepared in analogy to example 1 via a sequence of an alkylation reaction of 2-[(4-Hydroxy-7-methyl-indane-5-carbonyl)-amino]-2-methyl-propionic acid methyl ester using 1-bromomethyl-4-trifluoromethyl-benzene and a basic hydrolysis of the amino acid ester to the free amino acid

Sources & evidence

ORD record
ord-fda581e3ca644a71814a3cb802adc396
Source dataset
uspto-grants-2014_02
Patent number
US08642643B2

Reaction notes

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