1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 25027637, compound

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Reaction Steps

2-Methyl-2-{[7-methyl-4-(4-trifluoromethyl-benzyloxy)-indane-5-carbonyl]-amino}-propionic acid was prepared in analogy to example 1 via a sequence of an alkylation reaction of 2-[(4-Hydroxy-7-methyl-indane-5-carbonyl)-amino]-2-methyl-propionic acid methyl ester using 1-bromomethyl-4-trifluoromethyl-benzene and a basic hydrolysis of the amino acid ester to the free amino acid

Provenance & Evidence