反应详情

A solution of tert-butyl azetidin-3-ylcarbamate hydrochloride (prepared according to J. Antibiot. 1986, 39, 1243-1256, 0.755 g), Proton-Sponge® (0.85 g) and sulfamide (0.42 g) in dioxane (23 ml) was heated at reflux for 48 h. The residue was partitioned between H2O and EtOAc, and the aqueous layer then extracted with further EtOAc (×4). The combined organic extracts were washed quickly with 2 M aqueous hydrochloric acid (×3) then with saturated aqueous sodium bicarbonate, H2O and saturated aqueous sodium chloride, dried with sodium sulfate, filtered and evaporated to afford the subtitle compound as a pale brown powder.

1. temperatureat reflux for 48 h
2. customThe residue was partitioned between H2O and EtOAc
3. extractionthe aqueous layer then extracted with further EtOAc (×4)
4. washThe combined organic extracts were washed quickly with 2 M aqueous hydrochloric acid (×3)
5. dry with materialwith saturated aqueous sodium bicarbonate, H2O and saturated aqueous sodium chloride, dried with sodium sulfate
6. filtrationfiltered
7. customevaporated