Dimethylamine → 2,3-difluoro-5-iodo-N,N-dimethyl-benzamide

Temperature

0 °C

2,3 Difluoro-5-iodobenzoic acid (10.8 g, 38 mmol) was suspended in 80 mL of dry dichloromethane under nitrogen. Di-iso-propylethylamine (6.6 mL, 38 mmol) was added and the mixture was cooled to 0° C. Pivaloyl chloride (4.7 mL, 38 mmol) was added and the solution was stirred at 0° C. for 1.5 hrs. Dimethylamine was added (40% wt. solution in water, 10.6 mL, 83 mmol) and the reaction mixture was stirred for 5 hrs. The reaction was quenched with sodium bicarbonate and diluted with dichloromethane (50 mL). The layers were separated, the organic phase was washed with 1 N hydrochloric acid and brine. The organic phase was dried over magnesium sulfate and concentrated to give 10.3 g (33 mmol, 87%) of 2,3-difluoro-5-iodo-N,N-dimethyl-benzamide as a colorless solid. 1H NMR (500 MHz, DMSO-d6) δ 7.95 (ddd, J1=10 Hz, J2=7.5 Hz, J3=2 Hz, 1H), 7.57 (dt, J1=10 Hz, J2=2 Hz, 1H), 2.98 (s, 3H), 2.84 (s, 3H); MS: m/z 312 [MH+]

1. stirringthe reaction mixture was stirred for 5 hrs
2. customThe reaction was quenched with sodium bicarbonate
3. additiondiluted with dichloromethane (50 mL)
4. customThe layers were separated
5. washthe organic phase was washed with 1 N hydrochloric acid and brine
6. dry with materialThe organic phase was dried over magnesium sulfate
7. concentrationconcentrated

ORD record

ord-76459d9bbcbb43eb96a596e1fecceafe

Source dataset

uspto-grants-2012_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08268994B2