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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389148Generated: October 30, 2026

HCID 178445729, compound → HCID 178445753, compound

https://huagongshe.com/reaction/2389148

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 178445729HCID 178445729—
ReactantHCID 178445751HCID 178445751—
ProductHCID 178445753HCID 17844575348%

Reaction Steps

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(pyrimidin-5-yl)naphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 48% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(pyrimidin-5-yl)naphthalen-2-yl)-4-methyloxazolidin-2-one as starting material.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08269043B2
Source datasetuspto-grants-2012_09
ORD IDord-f827455276304034afc2bb23547cb5e0
Source noteuspto-grants-2012_09