Bromine → HCID 12273165, compound

HRID 2389258Notes

Reaction equation

HRID 2389258 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11](=[O:13])[CH3:12].[Br:14]Br>>[Br:14][CH2:12][C:11]([C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[Cl:1])=[O:13]

Participants

3

Reactant 2

HCID 24408BromineHCID 899961-(2-Chloro-5-nitrophenyl)ethan-1-one

Product 1

HCID 12273165HCID 12273165, compoundYield 96%

Procedure

Procedure A was performed with 2′-chloro-5′-nitro-acetophenone (4.0 g, 20 mmol) and bromine (1.13 ml, 22 mmol). The crude product was purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (0:1 to 1:4) to afford the desired 2-bromo-2′chloro-5′-nitroacetophenone (5.4 g, 19.2 mmol).

Workup

  1. customThe crude product was purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (0:1 to 1:4)

Sources & evidence

ORD record
ord-0d43354f6a2f4af8ad7ef9c622e41b71
Source dataset
uspto-grants-2012_09
Patent number
US08273743B2

Reaction notes

Loading…