反应详情

温度

0 °C

The tert-butyl 4-[2-(aminocarbonyl)-1-benzofuran-5-yl]piperazine-1-carboxylate (85 mg, 0.246 mmol) was dissolved in 5 mL of DCM and cooled to 0° C. under nitrogen. Triethylamine (0.075 mL, 0.541 mmol) was added, followed by trifluoroacetic anhydride (0.038 mL, 0.271 mmol). The reaction was stirred for 1 hour, then was diluted with additional 20 mL of DCM and washed with water (2×40 mL). The organic layers were combined, dried over sodium sulfate, filtered and concentrated to afford tert-butyl 4-(2-cyano-1-benzofuran-5-yl)piperazine-1-carboxylate.

1. washwashed with water (2×40 mL)
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated