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Dichloromethane → 4-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Tert-butyl 4-(2-cyano-1-benzofuran-5-yl)piperazine-1-carboxylate | HCID 67154775 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride | HCID 67154919 | — |
反応手順
The above piperazine (85.3 mg, 0.261 mmol) was dissolved in 5 mL of DCM and 5 mL of EtOAc, and cooled to 0° C. Hydrogen chloride gas was bubbled through the mixture for 30 seconds. The reaction stirred for 30 minutes, warming to ambient temperature. The slurry was concentrated to afford 4-(2-cyano-1-benzofuran-5-yl)piperazin-1-ium chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08273737B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-c928fe962c8f4c38b5c9417102e38a94 |
| 出典メモ | uspto-grants-2012_09 |