Diethyl methylmalonate → HCID 58022551, compound

HRID 2389306Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:19][CH2:20][CH2:21]I.[CH3:23][CH:24]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[Cl:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:19][CH2:20][CH2:21][C:24]([CH3:23])([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:30]([O:32][CH2:33][CH3:34])=[O:31]

Participants

Reactant 2

HCID 11857Diethyl methylmalonate

HCID 22287587HCID 22287587, compound

Product 1

HCID 58022551HCID 58022551, compound

Procedure

2-Chloro-1-(3-iodopropyl)-4-(3-trifluoromethylphenylthio) benzene and diethyl 2-methylmalonate were reacted according to the same procedures as in Example 152 of WO 04026817 to obtain the target product as a colorless oil.

Sources & evidence

ORD record: ord-eedf0693f658438f8bd3320447d38319
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273748B2

Reaction notes

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