反应详情

To a solution of 3-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)phenol (1.78 g) in MeCN (10 mL) were added methyl propiolate (0.667 mL) and NMM (0.0441 mL) at ambient temperature and the mixture was stirred at the same temperature for 3 hours. The solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=97:3) to afford methyl (2E)-3-[3-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)phenoxy]-acrylate (1.80 g) as a colorless oil.

1. customThe solvent was evaporated in vacuo
2. customThe residue was purified by silica gel column chromatography (n-hexane:EtOAc=97:3)