反应详情

To a stirring solution of [3-(benzyloxy)-4-fluorophenyl]methanol (14 mg) in DCM (0.7 mL) was added manganese dioxide (140 mg) at ambient temperature. After 22 hours, the reaction mixture was filtered through a bed of Celite and evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=10:1) to give 3-(benzyloxy)-4-fluorobenzaldehyde (13 mg).

1. filtrationthe reaction mixture was filtered through a bed of Celite
2. customevaporated in vacuo
3. customThe residue was purified by silica gel column chromatography (n-hexane:EtOAc=10:1)