HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3-(phenylmethoxy)benzenemethanol → 3-(Benzyloxy)-4-fluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3-(phenylmethoxy)benzenemethanol | HCID 561440 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(Benzyloxy)-4-fluorobenzaldehyde | HCID 561335 | 93.7% |
Reaction Steps
To a stirring solution of [3-(benzyloxy)-4-fluorophenyl]methanol (14 mg) in DCM (0.7 mL) was added manganese dioxide (140 mg) at ambient temperature. After 22 hours, the reaction mixture was filtered through a bed of Celite and evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=10:1) to give 3-(benzyloxy)-4-fluorobenzaldehyde (13 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273745B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-5dc314935a024a769c784718ca4e337b |
| Source note | uspto-grants-2012_09 |