HCID 86637908, compound → HCID 68540248, compound

HRID 2389348Notes

Reaction equation

HRID 2389348 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:15]=[CH:16][CH:17]=1)[O:8]/[CH:9]=[CH:10]/[C:11]([O:13][CH3:14])=[O:12]>CO.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:15]=[CH:16][CH:17]=1)[O:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 86637908HCID 86637908, compound

Product 1

HCID 68540248HCID 68540248, compoundYield 90.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of methyl (2E)-3-[3-(3-hydroxypropyl)phenoxy]acrylate (300 mg) in MeOH (4.0 mL) was added 10% palladium on carbon (50 mg) at ambient temperature and the mixture was stirred at ambient temperature for 4 hours under hydrogen atmosphere (3 atms). The mixture was filtered through a bed of celite. The filtrate was evaporated in vacuo to afford methyl 3-[3-(3-hydroxypropyl)phenoxy]propanoate (275 mg) as a colorless oil.

Workup

  1. filtrationThe mixture was filtered through a bed of celite
  2. customThe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-263123cf9c3443868e6af5f197de7d6f
Source dataset
uspto-grants-2012_09
Patent number
US08273745B2

Reaction notes

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