HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 3-chloro-5-(diphenylmethyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-(Diphenylmethyl)-2-pyridone | HCID 22748810 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-chloro-5-(diphenylmethyl)pyridin-2(1H)-one | HCID 68533619 | 91.3% |
Reaction Steps
A mixture of 5-(diphenylmethyl)pyridin-2(1H)-one (0.3 g) and N-chlorosuccinimide(0.184 g) in DMF (3 mL) was stirred at ambient temperature for 23 hours. The reaction mixture was poured into saturated NaHCO3 aqueous solution and the resulting precipitates were collected by filtration and washed with water to afford 3-chloro-5-(diphenylmethyl)pyridin-2(1H)-one (0.31 g) as white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273745B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-6705fa2fea984a8f8b092e5008b27426 |
| Source note | uspto-grants-2012_09 |