Ethyl Acetate → Ethyl acetate acetate

HRID 2389462Notes

Reaction equation

HRID 2389462 reaction equation
[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2]>C(O)(=O)C>[C:1]([OH:4])(=[O:3])[CH3:2].[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 8857Ethyl Acetate

Product 1

HCID 22609514Ethyl acetate acetate

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Polymorph A (158 mg) was dissolved in acetic acid (1 mL). The filtered solution was added dropwise to ethyl acetate (10 mL). Crystallization started 2 h after complete addition of the solution. The suspension was stirred for additional 2 h, the crystals were filtered off and dried under vacuum to give 45 mg of polymorph B.

Workup

  1. customCrystallization
  2. additionafter complete addition of the solution
  3. filtrationthe crystals were filtered off
  4. customdried under vacuum
  5. customto give 45 mg of polymorph B

Sources & evidence

ORD record
ord-ed5f2422c38948409d019787a7ccf2ad
Source dataset
uspto-grants-2012_09
Patent number
US08273753B2

Reaction notes

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