5-Bromo-2-ethoxybenzaldehyde → 4'-Ethoxy-3'-formyl-biphenyl-4-carbonitrile

HRID 2389582Notes

Reaction equation

HRID 2389582 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)#[N:2].Br[C:13]1[CH:14]=[CH:15][C:16]([O:21][CH2:22][CH3:23])=[C:17]([CH:20]=1)[CH:18]=[O:19]>>[CH2:22]([O:21][C:16]1[CH:15]=[CH:14][C:13]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)=[CH:20][C:17]=1[CH:18]=[O:19])[CH3:23]

Participants

3

Reactant 2

HCID 1449015-Bromo-2-ethoxybenzaldehydeHCID 27343264-Cyanophenylboronic acid

Product 1

HCID 220496634'-Ethoxy-3'-formyl-biphenyl-4-carbonitrile

Procedure

4-cyanophenylboronic acid (500 mg, 3.40 mmol) is coupled to 5-bromo-2-ethoxybenzaldehyde (780 mg, 3.40 mmol) using Method A to give the title compound.

Sources & evidence

ORD record
ord-e517a6639ae649dca56e6e5b6308caad
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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