HRID2389600

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13098184

5-Bromo-N-methylpyrimidin-2-amine

C5H6BrN3

结构：COc1ccc(B(O)O)cc1CN(C(=O)c1sc2ccccc2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683646

未命名化合物

PRODUCTS

生成物

结构：CNc1ncc(-c2ccc(OC)c(CN(C(=O)c3sc4ccccc4c3Cl)C3CCC(NC)CC3)c2)cn1.Cl.Cl

HCID68314157

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from boronic acid 5 (25 mg, 43 μmol) and 5-bromo-2-(methylamino)pyrimidine (6.7 mg, 36 μmol) in accordance with Method L2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-562c08459a7e434dba255b3afd25363d
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

C([N:8]([CH3:40])[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:28][C:29]2[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=2[O:35][CH3:36])[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.Br[C:42]1[CH:43]=[N:44][C:45]([NH:48][CH3:49])=[N:46][CH:47]=1>>[ClH:27].[ClH:27].[CH3:36][O:35][C:34]1[CH:33]=[CH:32][C:31]([C:42]2[CH:43]=[N:44][C:45]([NH:48][CH3:49])=[N:46][CH:47]=2)=[CH:30][C:29]=1[CH2:28][N:15]([CH:12]1[CH2:13][CH2:14][CH:9]([NH:8][CH3:40])[CH2:10][CH2:11]1)[C:16]([C:18]1[S:22][C:21]2[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=2[C:19]=1[Cl:27])=[O:17]