5-Bromo-N-methylpyrimidin-2-amine → 3-Chloro-benzo[b]thiophene-2-carboxylic acid [2-methoxy-5-(2-methylamino-pyrimidin-5-yl)-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-N-methylpyrimidin-2-amine	HCID 13098184	—
Reactant	3-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chlorobenzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzene boronic acid	HCID 59683646	—
Product	3-Chloro-benzo[b]thiophene-2-carboxylic acid [2-methoxy-5-(2-methylamino-pyrimidin-5-yl)-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride	HCID 68314157	—

Reaction Steps

The title compound is prepared from boronic acid 5 (25 mg, 43 μmol) and 5-bromo-2-(methylamino)pyrimidine (6.7 mg, 36 μmol) in accordance with Method L2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273747B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-562c08459a7e434dba255b3afd25363d
Source note	uspto-grants-2012_09