HRID2389616

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7466

Ethanone, 1-(4-bromophenyl)-

C8H7BrO

结构：COc1ccc(B(O)O)cc1CN(C(=O)c1sc2c(F)ccc(F)c2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683509

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccc(C(C)=O)cc2)cc1CN(C(=O)c1sc2c(F)ccc(F)c2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683585

未命名化合物

PROCEDURE

实验过程

Boronic acid 9 (700 mg, 1.12 mmol) is coupled to 4′-bromoacetophenone (268 mg, 1.34 mmol) using Method A to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-281f6626915e4e49afa3591d2c1c2fec
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([N:8]([CH3:42])[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:30][C:31]2[CH:32]=[C:33](B(O)O)[CH:34]=[CH:35][C:36]=2[O:37][CH3:38])[C:16]([C:18]2[S:22][C:21]3[C:23]([F:28])=[CH:24][CH:25]=[C:26]([F:27])[C:20]=3[C:19]=2[Cl:29])=[O:17])[CH2:11][CH2:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Br[C:44]1[CH:49]=[CH:48][C:47]([C:50](=[O:52])[CH3:51])=[CH:46][CH:45]=1>>[C:50]([C:47]1[CH:48]=[CH:49][C:44]([C:33]2[CH:34]=[CH:35][C:36]([O:37][CH3:38])=[C:31]([CH2:30][N:15]([C:16]([C:18]3[S:22][C:21]4[C:23]([F:28])=[CH:24][CH:25]=[C:26]([F:27])[C:20]=4[C:19]=3[Cl:29])=[O:17])[CH:12]3[CH2:13][CH2:14][CH:9]([N:8]([CH3:42])[C:1](=[O:2])[O:3][C:4]([CH3:6])([CH3:5])[CH3:7])[CH2:10][CH2:11]3)[CH:32]=2)=[CH:45][CH:46]=1)(=[O:52])[CH3:51]