Hydrochloric Acid → 3-Chloro-benzo[b]thiophene-2-carboxylic acid (4'-chloromethyl-4-methoxy-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

HRID 2389627Notes

Reaction equation

[Cl:1][C:2]1[C:3]2[CH:45]=[CH:44][CH:43]=[CH:42][C:4]=2[S:5][C:6]=1[C:7]([N:9]([CH2:25][C:26]1[CH:27]=[C:28]([C:34]2[CH:39]=[CH:38][C:37]([CH2:40]O)=[CH:36][CH:35]=2)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH:10]1[CH2:15][CH2:14][CH:13]([N:16](C)[C:17](=O)OC(C)(C)C)[CH2:12][CH2:11]1)=[O:8].[ClH:46]>>[ClH:1].[Cl:46][CH2:40][C:37]1[CH:36]=[CH:35][C:34]([C:28]2[CH:29]=[CH:30][C:31]([O:32][CH3:33])=[C:26]([CH2:25][N:9]([CH:10]3[CH2:11][CH2:12][CH:13]([NH:16][CH3:17])[CH2:14][CH2:15]3)[C:7]([C:6]3[S:5][C:4]4[CH:42]=[CH:43][CH:44]=[CH:45][C:3]=4[C:2]=3[Cl:1])=[O:8])[CH:27]=2)=[CH:39][CH:38]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 59683467tert-Butyl {4-[(3-chloro-benzo[b]thiophene-2-carbonyl)-(4'-hydroxymethyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Product 1

HCID 866189733-Chloro-benzo[b]thiophene-2-carboxylic acid (4'-chloromethyl-4-methoxy-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride

Procedure

tert-Butyl carbamate 84 (10 mg, 15 μmol) is treated with HCl using Method F to afford the title compound.

Sources & evidence

ORD record: ord-0bb8e0a113fc4de7a3dd9dba734dc772
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273747B2

Reaction notes

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