反应详情

温度

60 °C

A stirred suspension of 4-bromobenzyl bromide (1.0 g, 4.0 mmol) and sodium methanesulfinate (2.04 g, 20 mmol) in DMF (10 mL) is heated 1 h at 60° C. The reaction mixture is then cooled to RT, diluted with water (200 mL) and extracted into EtOAc (3×25 mL). The combined EtOAc phases are washed with water (2×50 mL) and brine (25 mL) then dried (MgSO4) and reduced in vacuo to afford the title compound.

1. temperatureThe reaction mixture is then cooled to RT
2. extractionextracted into EtOAc (3×25 mL)
3. washThe combined EtOAc phases are washed with water (2×50 mL) and brine (25 mL)
4. dry with materialthen dried (MgSO4)