3-(Trifluoromethoxy)benzene-1-sulfonyl chloride → 3-[3-(3-Trifluoromethoxy-benzenesulfonylamino)-phenyl]-pyrrolidine-1-carboxylic acid methyl ester

HRID 238967Notes

Reaction equation

HRID 238967 reaction equation
[F:1][C:2]([F:29])([F:28])[O:3][C:4]1[CH:5]=[C:6]([S:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C@@H]3CCN(CCC)C3)=[CH:16][CH:15]=2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1.[CH3:30][O:31][C:32]([N:34]1[CH2:38][CH2:37][CH:36](C2C=CC=C(N)C=2)[CH2:35]1)=[O:33].FC(F)(F)OC1C=C(S(Cl)(=O)=O)C=CC=1>>[CH3:30][O:31][C:32]([N:34]1[CH2:38][CH2:37][CH:36]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([NH:13][S:10]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:28])([F:1])[F:29])[CH:5]=3)(=[O:11])=[O:12])[CH:15]=2)[CH2:35]1)=[O:33]

Participants

4

Reactant 3

HCID 27772183-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 53628698N-[4-((S)-1-Propyl-pyrrolidin-3-yl)-phenyl]-3-trifluoromethoxy-benzenesulfonamideHCID 57470075Methyl 3-(3-aminophenyl)pyrrolidine-1-carboxylate

Product 1

HCID 689511843-[3-(3-Trifluoromethoxy-benzenesulfonylamino)-phenyl]-pyrrolidine-1-carboxylic acid methyl ester

Procedure

This compound was obtained following the same synthetic procedure as described for 3-trifluoromethoxy-N-[4-((S)-1-propyl-pyrrolidin-3-yl)-phenyl]-benzenesulfonamide by reacting 1-(Methoxycarbonyl)-3-(3-aminophenyl)-pyrrolidine as obtained in example b.1 with commercially available 3-trifluoromethoxy-benzenesulfonyl chloride.

Workup

  1. customThis compound was obtained

Sources & evidence

ORD record
ord-6f8ffb0385e44fec978fc3fcfce11804
Source dataset
uspto-grants-2014_02
Patent number
US08642642B2

Reaction notes

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