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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 238967Generated: October 25, 2026

3-(Trifluoromethoxy)benzene-1-sulfonyl chloride → 3-[3-(3-Trifluoromethoxy-benzenesulfonylamino)-phenyl]-pyrrolidine-1-carboxylic acid methyl ester

https://huagongshe.com/reaction/238967

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 2777218—
ReactantN-[4-((S)-1-Propyl-pyrrolidin-3-yl)-phenyl]-3-trifluoromethoxy-benzenesulfonamideHCID 53628698—
ReactantMethyl 3-(3-aminophenyl)pyrrolidine-1-carboxylateHCID 57470075—
Product3-[3-(3-Trifluoromethoxy-benzenesulfonylamino)-phenyl]-pyrrolidine-1-carboxylic acid methyl esterHCID 68951184—

Reaction Steps

This compound was obtained following the same synthetic procedure as described for 3-trifluoromethoxy-N-[4-((S)-1-propyl-pyrrolidin-3-yl)-phenyl]-benzenesulfonamide by reacting 1-(Methoxycarbonyl)-3-(3-aminophenyl)-pyrrolidine as obtained in example b.1 with commercially available 3-trifluoromethoxy-benzenesulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642642B2
Source datasetuspto-grants-2014_02
ORD IDord-6f8ffb0385e44fec978fc3fcfce11804
Source noteuspto-grants-2014_02