HRID2389670

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8058

Hexane

C6H14

HCID59683469

未命名化合物

PRODUCTS

产物

HCID86618978

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

tert-Butyl carbamate 205 (23 mg, 31 mmol) is deprotected using Method F. The isolated salt is then dissolved in the minimum amount of DCM and added dropwise to cold (0° C.) hexane (10 mL). The resultant cream precipitate is isolated by filtration and dried to afford the title compound.

WORKUP

后处理

customThe resultant cream precipitate is isolated by filtration
customdried

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-143c968eae9049ebbcf10c89ffc1c37e
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08273747B2
来源说明: uspto-grants-2012_09

反应SMILES

[Cl:1][C:2]1[C:3]2[C:49]([F:50])=[CH:48][CH:47]=[C:46]([F:51])[C:4]=2[S:5][C:6]=1[C:7]([N:9]([CH2:25][C:26]1[CH:27]=[C:28]([C:34]2[CH:39]=[CH:38][C:37]([N:40]([S:42]([CH3:45])(=[O:44])=[O:43])[CH3:41])=[CH:36][CH:35]=2)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH:10]1[CH2:15][CH2:14][CH:13]([N:16](C)[C:17](=O)OC(C)(C)C)[CH2:12][CH2:11]1)=[O:8].CCCCCC>C(Cl)Cl>[ClH:1].[CH3:45][S:42]([N:40]([CH3:41])[C:37]1[CH:38]=[CH:39][C:34]([C:28]2[CH:29]=[CH:30][C:31]([O:32][CH3:33])=[C:26]([CH2:25][N:9]([CH:10]3[CH2:11][CH2:12][CH:13]([NH:16][CH3:17])[CH2:14][CH2:15]3)[C:7]([C:6]3[S:5][C:4]4[C:46]([F:51])=[CH:47][CH:48]=[C:49]([F:50])[C:3]=4[C:2]=3[Cl:1])=[O:8])[CH:27]=2)=[CH:35][CH:36]=1)(=[O:43])=[O:44]