Hexane → HCID 86618978, compound

HRID 2389670Notes

Reaction equation

HRID 2389670 reaction equation
[Cl:1][C:2]1[C:3]2[C:49]([F:50])=[CH:48][CH:47]=[C:46]([F:51])[C:4]=2[S:5][C:6]=1[C:7]([N:9]([CH2:25][C:26]1[CH:27]=[C:28]([C:34]2[CH:39]=[CH:38][C:37]([N:40]([S:42]([CH3:45])(=[O:44])=[O:43])[CH3:41])=[CH:36][CH:35]=2)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH:10]1[CH2:15][CH2:14][CH:13]([N:16](C)[C:17](=O)OC(C)(C)C)[CH2:12][CH2:11]1)=[O:8].CCCCCC>C(Cl)Cl>[ClH:1].[CH3:45][S:42]([N:40]([CH3:41])[C:37]1[CH:38]=[CH:39][C:34]([C:28]2[CH:29]=[CH:30][C:31]([O:32][CH3:33])=[C:26]([CH2:25][N:9]([CH:10]3[CH2:11][CH2:12][CH:13]([NH:16][CH3:17])[CH2:14][CH2:15]3)[C:7]([C:6]3[S:5][C:4]4[C:46]([F:51])=[CH:47][CH:48]=[C:49]([F:50])[C:3]=4[C:2]=3[Cl:1])=[O:8])[CH:27]=2)=[CH:35][CH:36]=1)(=[O:43])=[O:44]

Participants

4

Reactant 2

HCID 8058HexaneHCID 59683469HCID 59683469, compound

Product 1

HCID 86618978HCID 86618978, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl carbamate 205 (23 mg, 31 mmol) is deprotected using Method F. The isolated salt is then dissolved in the minimum amount of DCM and added dropwise to cold (0° C.) hexane (10 mL). The resultant cream precipitate is isolated by filtration and dried to afford the title compound.

Workup

  1. customThe resultant cream precipitate is isolated by filtration
  2. customdried

Sources & evidence

ORD record
ord-143c968eae9049ebbcf10c89ffc1c37e
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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