2,6-Dimethyl-pyridin-4-yl trifluoromethanesulfonate → 3-Chloro-benzo[b]thiophene-2-carboxylic acid [5-(2,6-dimethyl-pyridin-4-yl)-2-ethoxy-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride

HRID 2389703Notes

Reaction equation

HRID 2389703 reaction equation
[C:1]([N:8](C)[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:28][C:29]2[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=2[O:35][CH2:36][CH3:37])[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.FC(F)(F)S(O[C:48]1[CH:53]=[C:52]([CH3:54])[N:51]=[C:50]([CH3:55])[CH:49]=1)(=O)=O>>[ClH:27].[ClH:27].[CH3:55][C:50]1[CH:49]=[C:48]([C:31]2[CH:32]=[CH:33][C:34]([O:35][CH2:36][CH3:37])=[C:29]([CH:30]=2)[CH2:28][N:15]([CH:12]2[CH2:13][CH2:14][CH:9]([NH:8][CH3:1])[CH2:10][CH2:11]2)[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH:53]=[C:52]([CH3:54])[N:51]=1

Participants

3

Reactant 2

HCID 216236792,6-Dimethyl-pyridin-4-yl trifluoromethanesulfonateHCID 596834943-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzene boronic acid

Product 1

HCID 683140943-Chloro-benzo[b]thiophene-2-carboxylic acid [5-(2,6-dimethyl-pyridin-4-yl)-2-ethoxy-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride

Procedure

The title compound was prepared from boronic acid (12) (25 mg, 42 μmol) and 2,6-dimethylpyridin-4-yl trifluoromethanesulphonate (91) (8.8 mg, 40 μmol) in accordance with Method L2.

Sources & evidence

ORD record
ord-c822b35212c346b5ac8b95f720c9150b
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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