2,6-Dimethyl-pyridin-4-yl trifluoromethanesulfonate → 3-Chloro-benzo[b]thiophene-2-carboxylic acid [5-(2,6-dimethyl-pyridin-4-yl)-2-ethoxy-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2,6-Dimethyl-pyridin-4-yl trifluoromethanesulfonate	HCID 21623679	—
Reactant	3-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzene boronic acid	HCID 59683494	—
Product	3-Chloro-benzo[b]thiophene-2-carboxylic acid [5-(2,6-dimethyl-pyridin-4-yl)-2-ethoxy-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride	HCID 68314094	—

Reaction Steps

The title compound was prepared from boronic acid (12) (25 mg, 42 μmol) and 2,6-dimethylpyridin-4-yl trifluoromethanesulphonate (91) (8.8 mg, 40 μmol) in accordance with Method L2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273747B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-c822b35212c346b5ac8b95f720c9150b
Source note	uspto-grants-2012_09