HRID2389708

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12594645

未命名化合物

结构：COc1ccc(-c2ccc(C)nc2)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683457

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccc(C)nc2)cc1CN(C(=O)c1sc2cccc(F)c2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59766920

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from amine (281) (200 mg, 0.45 mmol) and acid chloride 6 (170 mg, 6.8 mmol) following Method D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-66661ffa0d2a4469b253ac8ba729ea4d
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([O:5][C:6](=[O:32])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][CH2:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=3)[CH:20]=[CH:19][C:18]=2[O:30][CH3:31])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[Cl:33][C:34]1[C:35]2[C:45]([F:46])=[CH:44][CH:43]=[CH:42][C:36]=2[S:37][C:38]=1[C:39](Cl)=[O:40]>>[C:1]([O:5][C:6](=[O:32])[N:7]([CH:9]1[CH2:10][CH2:11][CH:12]([N:15]([C:39]([C:38]2[S:37][C:36]3[CH:42]=[CH:43][CH:44]=[C:45]([F:46])[C:35]=3[C:34]=2[Cl:33])=[O:40])[CH2:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:24]=[N:25][C:26]([CH3:29])=[CH:27][CH:28]=3)[CH:20]=[CH:19][C:18]=2[O:30][CH3:31])[CH2:13][CH2:14]1)[CH3:8])([CH3:4])([CH3:3])[CH3:2]