HCID 178454052, compound → HCID 178418966, compound

HRID 2389716Notes

Reaction equation

HRID 2389716 reaction equation
C(OC(=O)[NH:10][C@H:11]1[CH2:16][CH2:15][C@@H:14]([NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13][CH2:12]1)C1C=CC=CC=1>[Pd].CCO>[C:21]([O:20][C:18](=[O:19])[NH:17][C@H:14]1[CH2:13][CH2:12][C@@H:11]([NH2:10])[CH2:16][CH2:15]1)([CH3:24])([CH3:22])[CH3:23]

Participants

4

Reactant 1

HCID 178454052HCID 178454052, compound

Product 1

HCID 178418966HCID 178418966, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Cbz BOC diamine (294) (458 mg, 1.05 mmol) (containing residual benzyl alcohol) and 10% palladium on charcoal (92 mg, 20% by weight) in EtOH (9 mL) was stirred under a hydrogen atmosphere until the reaction was complete. The reaction was filtered through celite, washed with more EtOH and reduced in vacuo to give the title compound.

Workup

  1. filtrationThe reaction was filtered through celite
  2. washwashed with more EtOH

Sources & evidence

ORD record
ord-a0905112f8cd4a8fb1de498eb929cd9b
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

Loading…